The direct enantioselective copper hydride (CuH)-catalyzed synthesis of β-chiral amides from α,β-unsaturated carboxylic acids and secondary amines under mild reaction conditions is reported. The method utilizes readily accessible carboxylic acids and tolerates a variety of functional groups in the β-position including several heteroarenes. A subsequent iridium-catalyzed reduction to γ-chiral amines can be performed in the same flask without purification of the intermediate amides.
“CuH-Catalyzed Asymmetric Reductive Amidation of α,β-Unsaturated Carboxylic Acids”, Org. Lett., 2020, 22(14), 5666-5670.