Improved Functional Group Compatibility in the Palladium-Catalyzed Synthesis of Aryl Amines
“Improved Functional Group Compatibility in the Palladium-Catalyzed Synthesis of Aryl Amines”, Org. Lett., 2002, 4(17), 2885-2888.
The use of Pd(2)dba(3) with bulky, electron-rich ligands 1 or 2 and LIN(TMS)(2) as the base for the coupling of amines with aryl halides containing hydroxyl, amide, or enolizable keto groups is described. This protocol expands the utility of palladium-catalyzed C-N bond formation by allowing for the use of aryl halides containing these functional groups, obviating the need for protecting group manipulations.