Ligand-Controlled Asymmetric Arylation of Aliphatic α-Amino Anion Equivalents
“Ligand-Controlled Asymmetric Arylation of Aliphatic α-Amino Anion Equivalents”, J. Am. Chem. Soc., 2014, 136(12), 4500 - 4503.
Abstract:
A palladium-catalyzed asymmetric arylation of 9-aminofluorene-derived imines using a chiral dialkylbiaryl phosphine as the supporting ligand has been developed. This transformation allows for enantioselective access to a diverse range of α-branched benzylamines.A palladium-catalyzed asymmetric arylation of 9-aminofluorene-derived imines using a chiral dialkylbiaryl phosphine as the supporting ligand has been developed. This transformation allows for enantioselective access to a diverse range of α-branched benzylamines.