A wide range of biaryls were synthesized by palladium-catalyzed Negishi cross-couplings at ambient temperature or with low catalyst loading. This protocol features the use of a recently reported aminobiphenyl palladacycle precatalyst to generate the catalytically active XPhosPd0 species. Significantly, a wide range of challenging heterocyclic and polyfluorinated aromatic substrates can be employed to give products in excellent yields.
“Mild and General Conditions for Negishi Cross-Coupling Enabled by the Use of Palladacycle Precatalysts”, Angew. Chem. Int. Ed., 2013, 52(2), 615-619.