A Ni(0)−BINAP system is utilized for the highly enantioselective α-arylation of α-substituted γ-butyrolactones with aryl chlorides and bromides. α-Quaternization is achieved in moderate to excellent yields. Furthermore, the rate accelerating effect caused by the addition of Zn(II) salts is investigated.
“Nickel-BINAP Catalyzed Enantioselective α-Arylation of α-Substituted γ-Butyrolactones”, J. Am. Chem. Soc., 2002, 124(14), 3500-3501.