The first method for the highly enantioselective rhodium-catalyzed hydroformylation of 1,1-disubstituted olefins has been developed. By employing either of the P-chirogenic phosphine ligands BenzP* and QuinoxP*, linear aldehydes with beta-chirality can be prepared in a highly enantioselective fashion with good chemo- and regioselectivities.
“Rh-catalyzed asymmetric hydroformylation of functionalized 1,1-disubstituted olefins”, J. Am. Chem. Soc., 2011, 133(47), 19080-3.