Synthesis of Chiral 3-Substituted Indanones via an Enantioselective Reductive-Heck Reaction
“Synthesis of Chiral 3-Substituted Indanones via an Enantioselective Reductive-Heck Reaction”, J. Org. Chem., 2007, 72(24), 9253-9258.
An efficient intramolecular palladium-catalyzed, asymmetric reductive-Heck reaction has been developed, which allowed for the synthesis of either enantiomerically enriched 3-substituted indanones or alpha-exo-methylene indanones depending on the base used.