Transition metal-catalyzed systems offer a straightforward route for the formation of carbon−carbon bonds. Suzuki−Miyaura, Heck, and Negishi cross coupling are all classical methods for introducing molecular complexity and for simplifying the synthesis of desired targets. Our lab is interested in the continued development of systems for carbon−carbon bond formation. Much of this work relies on the practicality and robustness of the approach, which is often achieved through mechanistic understanding, ligand design and catalyst development.