Bower, S.
Kreutzer, K. A.
Buchwald, S. L.

A mild general procedure for the one-pot conversion of amides to aldehydes

“,
Angew. Chem. Int. Ed.
,
1996
,
35
(
13-14
)
,
1515-1516
.
Abstract

A wide range of amides containing different functional groups were readily converted into their corresponding aldehydes by means of a simple protocol. The reaction with [Ti(OiPr)4] and Ph2SiH2 proceeds at room temperature via an enamine intermediate, which is then hydrolyzed to afford the aldehyde