Buchwald, Stephen L.
Fang, Qun
King, Susan M.

A new method for the preparation of 3,5-disubstituted butenolides

“,
Tet. Lett.
,
1988
,
29
(
28
)
,
3445-3448
.
Abstract

A convenient method for the transformation of suitably protected propargyl alcohols into 3,5-disubstiuted butenolides has been developed. This organozirconium-based method transforms optically active propargyl alcohols into the corresponding butenolides with no loss of optical activity.