Biaryl monophosphine ligands in palladium-catalyzed C–N coupling: An updated User's guide
“Biaryl monophosphine ligands in palladium-catalyzed C–N coupling: An updated User's guide”, Tetrahedron, 2019, 75(32), 4199-4211.
Over the past three decades, Pd-catalyzed cross-coupling reactions have become a mainstay of organic synthesis. In particular, catalysts derived from biaryl monophosphines have shown wide utility in forming C–N bonds under mild reaction conditions. This work summarizes a variety of C–N cross-coupling reactions using biaryl monophosphines as supporting ligands, with the goal of directing synthetic chemists towards the ligands and conditions best suited for a particular coupling.