An efficient and modular synthesis of biaryls under continuous-flow conditions has been realized by a lithiation/borylation/Suzuki–Miyaura cross-coupling sequence under ambient conditions. Aryl bromides and heteroaromatic precursors can be transformed in the room-temperature lithiation reaction with nBuLi, followed by borylation and Suzuki–Miyaura coupling with the aid of ultrasonic irradiation.
“Continuous-flow synthesis of biaryls enabled by multistep solid-handling in a lithiation/borylation/Suzuki-Miyaura cross-coupling sequence”, Angew. Chem. Int. Ed., 2011, 50(45), 10665-10669.