Copper-Catalyzed Arylation of β-Amino Alcohols
“Copper-Catalyzed Arylation of β-Amino Alcohols”, Org. Lett., 2002, 4(21), 3703-3706.
Methods for synthesizing N-aryl beta-amino alcohols and O-aryl beta-amino alcohols are described. The presence of a neighboring hydroxyl or amino group, respectively, is thought to activate beta-amino alcohols toward these transformations. These protocols significantly increase access to a variety of arylated beta-amino alcohols.