Copper-Catalyzed Coupling of Arylboronic Acids and Amines
“Copper-Catalyzed Coupling of Arylboronic Acids and Amines”, Org. Lett., 2001, 3(13), 2077-2079.
A general catalytic coupling of arylboronic acids and amines is reported. This room-temperature coupling was realized through the use of catalytic copper(II) acetate, 2,6-lutidine as base, and myristic acid as an additive. Functionalized aniline substrates provided the diarylamine coupling products in good yield (58-91%), A variety of alkylamines were also successfully coupled to give N-alkyl anilines in moderate yield (50-64%).