A copper-based catalytic technique for the regioselective ortho CH cyanation of vinylarenes has been developed. This method provides an effective means for the selective functionalization of vinylarene derivatives. A copper-catalyzed cyanative dearomatization mechanism is proposed to account for the regiochemical course of this reaction.
“Copper-Catalyzed Regioselective ortho C–H Cyanation of Vinylarenes”, Angew. Chem. Int. Ed., 2014, 53(33), 8677 - 8681.