The first multistep asymmetric catalysis in flow has been realized using a lithiation/borylation/rhodium-catalyzed 1,4-addition sequence. The three-step sequence starts from readily available and inexpensive aryl bromides, affording β-arylated ketones in good yields with high levels of enantioselectivity.
“Enantioselective β-arylation of ketones enabled by lithiation/borylation/1,4-addition sequence under flow conditions”, Angew. Chem. Int. Ed., 2012, 51, 5355-5358.