Aryl bromides are coupled with amines in the presence of a palladium catalyst and a stoichiometric amount of cesium carbonate. Using these conditions base-sensitive functional groups, which were incompatible with our previously reported catalytic-amination reaction conditions, are well tolerated. (C) 1997 Elsevier Science Ltd.
“Improved functional group compatibility in the palladium-catalyzed amination of aryl bromides”, Tet. Lett., 1997, 38(36), 6359-6362.