An improved protocol for the Pd-catalyzed alpha-arylation of aldehydes with aryl halides has been developed. The new catalytic system allows for the coupling of an array of substrates including challenging electron-rich aryl bromides and less reactive aryl chlorides. The utility of this method has been demonstrated in a new total synthesis of (+/-)-sporochnol.
“An Improved Protocol for the Pd-Catalyzed α-Arylation of Aldehydes with Aryl Halides”, Org. Lett., 2008, 10(20), 4561-4564.