The combination of feedback control and continuous-flow operations in microreactors enables online and fully automated reaction optimization. A Heck reaction demonstrates the potential for rapid multivariable reaction optimization while requiring a minimal amount of material. Optimal conditions are quickly scaled-up by a factor of 50.
“An integrated microreactor system for self-optimization of a Heck reaction: from micro- to mesoscale flow systems”, Angew. Chem. Int. Ed., 2010, 49(39), 7076-7080.