An efficient copper-catalyzed amination of aryl bromides with primary alkylamines was developed that uses commercially available diethylsalicylamide as the ligand. This amination reaction can be performed at 90 degreesC in good yield. A variety of functional groups are compatible with these reaction conditions. Preliminary results show that this reaction can be carried out under solvent-free conditions with comparable yields.
“Mild and Efficient Copper-Catalyzed Amination of Aryl Bromides with Primary Alkylamines”, Org. Lett., 2003, 5(6), 793-796.