Palladium-Catalyzed Amination of Unprotected Halo-7-azaindoles
“Palladium-Catalyzed Amination of Unprotected Halo-7-azaindoles”, Org. Lett., 2010, 12(20), 4438-4441.
Simple and efficient procedures for the Pd-catalyzed cross-coupling of primary and secondary amines with halo-7-azaindoles(pyrrolo[2,3-b]pyridine) are presented. Previously, no general method was available to ensure the highly selective reaction of the heteroaryl halide in the presence of the unprotected azaindole N-H. Using palladium precatalysts recently reported by our group, such reactions are easily accomplished under mild conditions that can be applied to cross-coupling reactions with a wide array of aliphatic and aromatic amines.