The Balz–Schiemann reaction remains a highly utilized means for preparing aryl fluorides from anilines. However, the limitations associated with handling aryl diazonium salts often hinder both the substrate scope and scalability of this reaction. To address this, a new continuous flow protocol was developed that eliminates the need to isolate the aryl diazonium salts. The new process has enabled the fluorination of an array of aryl and heteroaryl amines.
“Rapid Synthesis of Aryl Fluorides in Continuous Flow through the Balz–Schiemann Reaction”, Angew. Chem. Int. Ed. , 2016, 55(39), 11907-11911.