Synthesis of Optically Pure 2-Trifluoromethyl Lactic Acid by Asymmetric Hydroformylation
“Synthesis of Optically Pure 2-Trifluoromethyl Lactic Acid by Asymmetric Hydroformylation”, J. Org. Chem., 2013, 78(7), 3429 - 3433.
Abstract:
By utilizing Rh catalysts ligated by the P-chirogenic ligands QuinoxP* and DuanPhos, 3,3,3-trifluoroprop-1-en-2-yl acetate could be hydroformylated and subsequently oxidized to yield enantiomerically pure 2-trifluoromethyllactic acid.