Altman, Ryan A.
Buchwald, Stephen L.

4,7-Dimethoxy-1,10-phenanthroline:  An Excellent Ligand for the Cu-Catalyzed N-Arylation of Imidazoles

“,
Org. Lett.
,
2006
,
8
(
13
)
,
2779-2782
.
Abstract

4,7-Dimethoxy-1,10-phenanthroline (L) was found to be an efficient ligand for the copper-catalyzed N-arylation of imidazole with aryl iodides and bromides under mild conditions. A variety of hindered and functionalized imidazoles and aryl halides were transformed in good to excellent yields.