Wang, Xiao
Buchwald, Stephen L.

Synthesis of Optically Pure 2-Trifluoromethyl Lactic Acid by Asymmetric Hydroformylation

“,
J. Org. Chem.
,
2013
,
78
(
7
)
,
3429 – 3433
.
Abstract

By utilizing Rh catalysts ligated by the P-chirogenic ligands QuinoxP* and DuanPhos, 3,3,3-trifluoroprop-1-en-2-yl acetate could be hydroformylated and subsequently oxidized to yield enantiomerically pure 2-trifluoromethyllactic acid.