An efficient and modular synthesis of biaryls under continuous-flow conditions has been realized by a lithiation/borylation/Suzuki–Miyaura cross-coupling sequence under ambient conditions. Aryl bromides and heteroaromatic precursors can be transformed in the room-temperature lithiation reaction with nBuLi, followed by borylation and Suzuki–Miyaura coupling with the aid of ultrasonic irradiation.