A Domino Copper-Catalyzed C−O Coupling−Claisen Rearrangement Process
“A Domino Copper-Catalyzed C−O Coupling−Claisen Rearrangement Process”, J. Am. Chem. Soc., 2003, 125(17), 4978-4979.
A practical method for the diastereoselective generation of two adjacent quarternary stereocenters by combining a copper-catalyzed C−O coupling reaction with a subsequent Claisen rearrangement in a one-pot domino process is described. Furthermore, an experimentally simple method for the stereoselective synthesis of a variety of different types of vinyl ethers is delineated using the same catalyst system.