Efficient Pd-Catalyzed Amination of Heteroaryl Halides
“Efficient Pd-Catalyzed Amination of Heteroaryl Halides”, Org. Lett., 2005, 7(18), 3965-3968.
The Pd-catalyzed amination of a variety of heteroaryl halides has been accomplished by utilizing bulky electron-rich biaryl phosphine ligands. In particular, we report the first couplings of amines with chloro- and bromoindoles bearing a free NH, as well as the first Pd-catalyzed aminations of a 5-halopyrimidine.