The methylenation of enolizable ketones and esters using organotitanium chemistry
“The methylenation of enolizable ketones and esters using organotitanium chemistry”, Tet. Lett., 1984, 25(50), 5733-5736.
Abstract:
The titanium methylidene fragment, Cp2TiCH2, resulting from Tebbe's reagent, Cp2TiCH2·AlMe2Cl or the β,β-disubstituted metallacycle, CP2TiCH2C(Me)(n-Pr)CH2, methylenates enolizable acidic ketones and converts α,α-disubstituted ketones into titanium enolates. The reagent reacts selectively with ketones over esters.