A mild general procedure for the one-pot conversion of amides to aldehydes
“A mild general procedure for the one-pot conversion of amides to aldehydes”, Angew. Chem. Int. Ed., 1996, 35(13-14), 1515-1516.
A wide range of amides containing different functional groups were readily converted into their corresponding aldehydes by means of a simple protocol. The reaction with [Ti(OiPr)4] and Ph2SiH2 proceeds at room temperature via an enamine intermediate, which is then hydrolyzed to afford the aldehyde