A continuous-flow, multistep Heck synthesis was made possible by integrating microreactors, liquid–liquid extraction, and microfluidic distillation. The microfluidic distillation enabled solvent exchange from CH2Cl2 in the first reaction step to N,N-dimethylformamide (DMF) in the final reaction step.
“Multistep microchemical synthesis enabled by microfluidic distillation”, Angew. Chem. Int. Ed., 2010, 49(5), 899-903.