A catalyst system able to operate at temperatures as low as -65 degrees C for the Pd-catalyzed Kumada-Corriu cross-coupling reaction is described. This unprecedented level of activity allows the use of highly functionalized (Knochel-type) Grignard reagents. Additionally, the tolerance of the protocol toward a wide variety of functional groups allows for the synthesis of valuable compounds, including heterocyclic or polyfluoro biaryls.
“Pd-Catalyzed Kumada−Corriu Cross-Coupling Reactions at Low Temperatures Allow the Use of Knochel-type Grignard Reagents”, J. Am. Chem. Soc., 2007, 129(13), 3844-3845.