Preparation of 2-amino-2′-hydroxy-1,1′-binaphthyl and N-arylated 2-amino-1,1′-binaphthyl derivatives via palladium-catalyzed amination

R. Singer and Buchwald, S. “Preparation of 2-amino-2′-hydroxy-1,1′-binaphthyl and N-arylated 2-amino-1,1′-binaphthyl derivatives via palladium-catalyzed amination”, Tet. Lett., 1999, 40(6), 1095-1098.

Abstract:

Palladium-catalyzed amination reactions were carried out with 2-triflato-2'-(4-methoxybenzyloxy)-1,1'-binaphthyl (5) and benzophenone imine followed by hydrolysis of the imine and hydrogenolysis of the benzyl protecting group to afford 2-amino-2'-hydroxy-1,1'-binaphthyl. Arylamines were also coupled successfully with 5 under similar conditions.

Authors

Robert A. Singer