Synthesis of Indolines via a Domino Cu-Catalyzed Amidation/Cyclization Reaction
“Synthesis of Indolines via a Domino Cu-Catalyzed Amidation/Cyclization Reaction”, Org. Lett., 2008, 10(13), 2721-2724.
A highly efficient one-pot procedure for the synthesis of indolines and their homologues based on a domino Cu-catalyzed amidation/nucleophilic substitution reaction has been developed. Substituted 2-iodophenethyl mesylates and related compounds afforded the corresponding products in excellent yields. No erosion of optical purity was observed when transforming enantiomerically pure mesylates under the reaction conditions.