The development of methods for the construction of organofluorine compounds is of great importance due to the broad presence of fluorine in pharmaceuticals and agrochemicals. Fluorine substitution markedly changes the properties and behavior of the molecule (i.e. lipophilicity, cell membrane permeability, drug potency, and half-life time in the body). Thus, significant efforts have been made towards the development of new fluorination systems. Our research group has worked on methods for introducing fluorine atoms with the use of a palladium catalyst under mild conditions for late-stage functionalization of advanced synthetic intermediates. Mechanistic understanding and ligand development have been crucial for the success of a broadly applicable and efficient system. Fluorination is a vibrant area of research within our lab, and future efforts will be extended towards the development of radiochemical PET applications.