Chernyak, N.
Buchwald, S. L.

Continuous-flow synthesis of monoarylated acetaldehydes using aryldiazonium salts

J. Am. Chem. Soc.
,
2012
,
134
,
12466-12469
.
Abstract

Anilines and ethyl vinyl ether can be used as precursors for a process that is the synthetic equivalent of the alpha-arylation of acetaldehyde enolate. The reaction manifests a high level of functional group compatibility, allowing the ready preparation of a number of synthetically valuable compounds.