Wu, X.
Fors, B. P.
Buchwald, S. L.

A single phosphine ligand allows palladium-catalyzed intermolecular C-O bond formation with secondary and primary alcohols

“,
Angew. Chem. Int. Ed.
,
2011
,
50
(
42
)
,
9943-7
.
Abstract

Forging a bond: an efficient, general palladium catalyst for C-O bond-forming reactions of secondary and primary alcohols with a range of aryl halides has been developed using the ligand 1. Heteroaryl halides, and for the first time, electron-rich aryl halides can be coupled with secondary alcohols. A diverse set of substrate combinations are possible with just a single ligand, thus obviating the need to survey multiple ligands.