Bioconjugation

Automated Flow Synthesis of Artificial Heme Enzymes for Enantiodivergent Biocatalysis

G. Fittolani, Kutateladze, D. A. , Loas, A. , Buchwald, S. L. , and Pentelute, B. L. “Automated Flow Synthesis of Artificial Heme Enzymes for Enantiodivergent Biocatalysis”, J. Am. Chem. Soc., 2025, 147(5), 4188-4197.

Site-Specific Antibody Prodrugs via S‑Arylation: a Bioconjugation Approach Toward Masked Tyrosine Analogues

J. Tao, Dhanjee, H. H. , Gribble, Jr., M. W. , Kottisch, V. , Rodriguez, J. , Brown, J. S. , Schmidt, H. , Juneja, J. , Denhez, F. , Lee, P. S. , Lipovšek, D. , Krystek, S. , Zhang, Y. , Bousquet, P. , Zhang, Y. , Petelute, B. L. , and Buchwald, S. L. “Site-Specific Antibody Prodrugs via S‑Arylation: a Bioconjugation Approach Toward Masked Tyrosine Analogues”, J. Am. Chem. Soc., 2024, 146, 20080-20085.

Electrophile Scanning Reveals Reactivity Hotspots for the Design of Covalent Peptide Binders

N. M. Grob, Remarcik, C. , Rössler, S. L. , Wong, J. Y. K. , Wong, J. C. K. , Tao, J. , Smith, C. L. , Loas, A. , Buchwald, S. L. , Eaton, D. L. , López, M. P. , and Pentelute, B. L. “Electrophile Scanning Reveals Reactivity Hotspots for the Design of Covalent Peptide Binders”, ACS Chem. Biol., 2024, 19, 101-109.

Abiotic peptides as carriers of information for the encoding of small-molecule library synthesis

S. L. Rössler, Grob, N. M. , Buchwald, S. L. , and Pentelute, B. L. “Abiotic peptides as carriers of information for the encoding of small-molecule library synthesis”, Science, 2023, 379, 939–946.

Palladium−Peptide Oxidative Addition Complexes for Bioconjugation

A. Jose Rojas, Wolfe, J. M. , Dhanjee, H. H. , Buslov, I. , Truex, N. L. , Liu, R. Y. , Massefski, W. , Pentelute, B. , and Buchwald, S. L. “Palladium−Peptide Oxidative Addition Complexes for Bioconjugation”, Chem. Sci., 2022, 13, 11891-11895.

Palladium Mediated Synthesis of Protein–Polyarene Conjugates

J. Rodriguez, Dhanjee, H. H. , Pentelute, B. L. , and Buchwald, S. L. “Palladium Mediated Synthesis of Protein–Polyarene Conjugates”, J. Am. Chem. Soc., 2022, 144, 11706-11712.

Palladium-Mediated Incorporation of Carboranes into Small Molecules, Peptides, and Proteins

M. Gazvoda, Dhanjee, H. H. , Rodriguez, J. , Brown, J. S. , Farquhar, C. E. , Truex, N. L. , Loas, A. , Buchwald, S. L. , and Pentelute, B. L. “Palladium-Mediated Incorporation of Carboranes into Small Molecules, Peptides, and Proteins”, J. Am. Chem. Soc., 2022, 144(17), 7852-7860.

Engineering Bioactive Dimeric Transcription Factor Analogs via Palladium Rebound Reagents

M. Jbara, Pomplun, S. , Schissel, C. K. , Hawken, S. Wilson, Boija, A. , Klein, I. , Rodriguez, J. , Buchwald, S. L. , and Pentelute, B. L. “Engineering Bioactive Dimeric Transcription Factor Analogs via Palladium Rebound Reagents”, J. Am. Chem. Soc., 2021, 143, 11788-11798.

Selective N-Arylation of p-Aminophenylalanine in Unprotected Peptides with Organometallic Palladium Reagents

A. Mallek, Pentelute, B. L. , and Buchwald, S. L. “Selective N-Arylation of p-Aminophenylalanine in Unprotected Peptides with Organometallic Palladium Reagents”, Angew. Chem. Int. Ed., 2021, 60(31), 16928-16931.

Oligonucleotide Bioconjugation with Bifunctional Palladium Reagents

M. Jbara, Rodriguez, J. , Dhanjee, H. H. , Loas, A. , Buchwald, S. L. , and Pentelute, B. L. “Oligonucleotide Bioconjugation with Bifunctional Palladium Reagents”, Angew. Chem., Int. Ed. , 2021, 60(21), 12109-12115.

Pages