Cu-Catalyzed Amination of Base-Sensitive Aryl Bromides and the Chemoselective N- and O-Arylation of Amino Alcohols

M. J. Strauss, Liu, K. X. , Greaves, M. E. , Dahl, J. C. , Kim, S. - T. , Wu, Y. - J. , Schmidt, M. A. , Scola, P. M. , and Buchwald, S. L. “Cu-Catalyzed Amination of Base-Sensitive Aryl Bromides and the Chemoselective N- and O-Arylation of Amino Alcohols”, J. Am. Chem. Soc., 2024, 146, 18616-18625.

Room-Temperature Copper-Catalyzed Etherification of Aryl Bromides

M. J. Strauss, Greaves, M. E. , Kim, S. - T. , Teijaro, C. N. , Schmidt, M. A. , Scola, P. M. , and Buchwald, S. L. “Room-Temperature Copper-Catalyzed Etherification of Aryl Bromides”, Angewandte Chemie, 2024, e202400333. https://doi.org/10.1002/anie.202400333.

H. Zhang, Ruiz-Castillo, P. , Schuppe, A. W. , and Buchwald, S. L. “Improved Process for the Palladium-Catalyzed C–O Cross-Coupling of Secondary Alcohols”, Org. Lett., 2020, 22(14), 5369-5374.

H. Zhang, Ruiz-Castillo, P. , and Buchwald, S. L. “Palladium-Catalyzed C–O Cross-Coupling of Primary Alcohols”, Org. Lett., 2018, 20, 1580-1583.

O. J. Plante, Buchwald, S. L. , and Seeberger, P. H. “Halobenzyl Ethers as Protecting Groups for Organic Synthesis”, J. Am. Chem. Soc., 2000, 122(29), 7148-7149.

R. A. Widenhoefer, Zhong, H. A. , and Buchwald, S. L. “Direct observation of C-O reductive elimination from palladium aryl alkoxide complexes to form aryl ethers”, J. Am. Chem. Soc., 1997, 119(29), 6787-6795.

M. Palucki, Wolfe, J. P. , and Buchwald, S. L. “Palladium-catalyzed intermolecular carbon-oxygen bond formation: A new synthesis of aryl ethers”, J. Am. Chem. Soc., 1997, 119(14), 3395-3396.