Mechanistic Studies

Papers describing mechanistic studies.

Reevaluation of the Mechanism of the Amination of Aryl Halides Catalyzed by BINAP-Ligated Palladium Complexes

S. Shekhar, Ryberg, P. , Hartwig, J. F. , Mathew, J. S. , Blackmond, D. G. , Strieter, E. R. , and Buchwald, S. L. “Reevaluation of the Mechanism of the Amination of Aryl Halides Catalyzed by BINAP-Ligated Palladium Complexes”, J. Am. Chem. Soc., 2006, 128(11), 3584-3591.

New Insights into Xantphos/Pd-Catalyzed C−N Bond Forming Reactions: A Structural and Kinetic Study

L. M. Klingensmith, Strieter, E. R. , Barder, T. E. , and Buchwald, S. L. “New Insights into Xantphos/Pd-Catalyzed C−N Bond Forming Reactions: A Structural and Kinetic Study”, Organometallics, 2006, 25(1), 82-91.

The Role of Chelating Diamine Ligands in the Goldberg Reaction: A Kinetic Study on the Copper-Catalyzed Amidation of Aryl Iodides

E. R. Strieter, Blackmond, D. G. , and Buchwald, S. L. “The Role of Chelating Diamine Ligands in the Goldberg Reaction: A Kinetic Study on the Copper-Catalyzed Amidation of Aryl Iodides”, J. Am. Chem. Soc., 2005, 127(12), 4120-4121.

Insights into the Origin of High Activity and Stability of Catalysts Derived from Bulky, Electron-Rich Monophosphinobiaryl Ligands in the Pd-Catalyzed C−N Bond Formation

E. R. Strieter, Blackmond, D. G. , and Buchwald, S. L. “Insights into the Origin of High Activity and Stability of Catalysts Derived from Bulky, Electron-Rich Monophosphinobiaryl Ligands in the Pd-Catalyzed C−N Bond Formation”, J. Am. Chem. Soc., 2003, 125(46), 13978-13980.

Preparation, Crystal Structure Analysis, and Catalytic Application of [(S)-BINAP]Ni(COD) and [(S)-BINAP]NiBr2

D. J. Spielvogel, Davis, W. M. , and Buchwald, S. L. “Preparation, Crystal Structure Analysis, and Catalytic Application of [(S)-BINAP]Ni(COD) and [(S)-BINAP]NiBr2”, Organometallics, 2002, 21(18), 3833-3836.

Mechanistic Insights into the Pd(BINAP)-Catalyzed Amination of Aryl Bromides: Kinetic Studies under Synthetically Relevant Conditions

U. K. Singh, Strieter, E. R. , Blackmond, D. G. , and Buchwald, S. L. “Mechanistic Insights into the Pd(BINAP)-Catalyzed Amination of Aryl Bromides: Kinetic Studies under Synthetically Relevant Conditions”, J. Am. Chem. Soc., 2002, 124(47), 14104-14114.

Pd-Catalyzed Conversion of Aryl Chlorides, Triflates, and Nonaflates to Nitroaromatics

B. P. Fors and Buchwald, S. L. “Pd-Catalyzed Conversion of Aryl Chlorides, Triflates, and Nonaflates to Nitroaromatics”, J. Am. Chem. Soc., 2009, 131(36), 12898-12899.

An Efficient Process for Pd-Catalyzed C−N Cross-Coupling Reactions of Aryl Iodides: Insight Into Controlling Factors

B. P. Fors, Davis, N. R. , and Buchwald, S. L. “An Efficient Process for Pd-Catalyzed C−N Cross-Coupling Reactions of Aryl Iodides: Insight Into Controlling Factors”, J. Am. Chem. Soc., 2009, 131(16), 5766-5768.

Mechanistic Studies on the Copper-Catalyzed N-Arylation of Amides

E. R. Strieter, Bhayana, B. , and Buchwald, S. L. “Mechanistic Studies on the Copper-Catalyzed N-Arylation of Amides”, J. Am. Chem. Soc., 2009, 131(1), 78-88.

Computational Explorations of Mechanisms and Ligand-Directed Selectivities of Copper-Catalyzed Ullmann-Type Reactions

G. O. Jones, Liu, P. , Houk, K. N. , and Buchwald, S. L. “Computational Explorations of Mechanisms and Ligand-Directed Selectivities of Copper-Catalyzed Ullmann-Type Reactions”, J. Am. Chem. Soc., 2010, 132(17), 6205-6213.

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