Richard Liu | The Buchwald Research Group

Lab Positions	Start Date	End Date2	Fellowships and Awards	Degree Received	Previous Institutions
Postdoctoral Researcher, Graduate Student	2019	2020	2015-2016: Robert T. Haslam Presidential Graduate Fellowship 2017-2018: Bristol-Myers Squibb Graduate Fellowship in Synthetic Organic Chemistry	PhD	S.B.: Harvard University, Cambridge, MA Advisor: Prof. Eric N. Jacobsen Ph.D.: Massachusetts Institute of Technology, 2015-2019 Advisor: Stephen L. Buchwald

Palladium−Peptide Oxidative Addition Complexes for Bioconjugation	Rojas, A. Jose; Wolfe, J. M. ; Dhanjee, H. H. ; Buslov, I. ; Truex, N. L. ; Liu, R. Y. ; Massefski, W. ; Pentelute, B. ; Buchwald, S. L. . Chem. Sci. 2022, 13, 11891-11895.
The Quest for the Ideal Base: Rational Design of a Nickel Precatalyst Enables Mild, Homogeneous C–N Cross-Coupling	Liu, R. Y. ; Dennis, J. M. ; Buchwald, S. L. . J. Am. Chem. Soc. 2020, 142, 4500 - 4507.
CuH-Catalyzed Olefin Functionalization: From Hydroamination to Carbonyl Addition	Liu, R. Y. ; Buchwald, S. L. . Acc. Chem. Res. 2020, 53, 1229-1243.
Evidence for Simultaneous Dearomatization of Two Aromatic Rings Under Mild Conditions in Cu(I)-Catalyzed Direct Asymmetric Dearomatization of Pyridine	Gribble, M. W. ; Liu, R. Y. ; Buchwald, S. L. . J. Am. Chem. Soc. 2020, 142, 11252-11269.
Enantioselective Allylation Using Allene, a Petroleum Cracking Byproduct	Liu, R. Y. ; Zhou, Y. ; Yang, Y. ; Buchwald, S. L. . J. Am. Chem. Soc. 2019, 141, 2251-2256.
CuH-Catalyzed Enantioselective Ketone Allylation with 1,3-Dienes: Scope, Mechanism, and Applications	Li, C. ; Liu, R. Y. ; Jesikiewicz, L. T. ; Yang, Y. ; Liu, P. ; Buchwald, S. L. . J. Am. Chem. Soc. 2019, 141, 5062-5070.
Pd-Catalyzed C–N Coupling Reactions Facilitated by Organic Bases: Mechanistic Investigation Leads to Enhanced Reactivity in the Arylation of Weakly Binding Amines	Dennis, J. M. ; White, N. A. ; Liu, R. Y. ; Buchwald, S. L. . ACS Catalysis 2019, 9, 3822 - 3830.
Monophosphine Ligands Promote Pd-Catalyzed C–S Cross-Coupling Reactions at Room Temperature with Soluble Bases	Xu, J. ; Liu, R. Y. ; Yeung, C. S. ; Buchwald, S. L. . ACS Catalysis 2019, 9, 6461 - 6466.
Engaging Aldehydes in CuH-Catalyzed Reductive Coupling Reactions: Stereoselective Allylation with Unactivated 1,3-Diene Pronucleophiles	Li, C. ; Shin, K. ; Y.Liu, R. ; Buchwald, S. L. . Angew. Chem. Int. Ed. 2019, 58, 17074-17080.
CuH-Catalyzed Asymmetric Reduction of α,β-Unsaturated Carboxylic Acids to β-Chiral Aldehydes	Zhou, Y. ; Bandar, J. S. ; Liu, R. Y. ; Buchwald, S. L. . J. Am. Chem. Soc 2018, 140, 606-609.
Mechanistic Insight Facilitates Discovery of a Mild and Efficient Copper-Catalyzed Dehydration of Primary Amides to Nitriles Using Hydrosilanes	Liu, R. Y. ; Bae, M. ; Buchwald, S. L. . J. Am. Chem. Soc. 2018, 140, 1627-1631.
A Regio- and Enantioselective CuH-Catalyzed Ketone Allylation with Terminal Allenes	Tsai, E. ; Liu, R. Y. ; Yang, Y. ; Buchwald, S. L. . J. Am. Chem. Soc 2018, 140, 2007-2011.
Breaking the Base Barrier: An Electron-Deficient Palladium Catalyst Enables the Use of a Common, Soluble Base in C–N Coupling	Dennis, J. M. ; White, N. A. ; Liu, R. Y. ; Buchwald, S. L. . J. Am. Chem. Soc. 2018, 140, 4721–4725.
Copper-Catalyzed Enantioselective Hydroamination of Alkenes	Liu, R. Y. ; Buchwald, S. L. . Org. Syn. 2018, 95, 80-96.
Asymmetric Copper Hydride-Catalyzed Markovnikov Hydrosilylation of Vinylarenes and Vinyl Heterocycles	Gribble, M. W. ; Pirnot, M. T. ; Bandar, J. S. ; Liu, R. Y. ; Buchwald, S. L. . J. Am. Chem. Soc 2017, 139, 2192-2195.
Ligand-Substrate Dispersion Facilitates the Copper-Catalyzed Hydroamination of Unactivated Olefins	Lu, G. ; Liu, R. Y. ; Yang, Y. ; Fang, C. ; Lambrecht, D. S. ; Buchwald, S. L. ; Liu, P. . J. Am. Chem. Soc 2017, 139, 16548–16555.
Regiodivergent and Diastereoselective CuH-Catalyzed Allylation of Imines with Terminal Allenes	Liu, R. Y. ; Yang, Y. ; Buchwald, S. L. . Angew. Chem. Int. Ed. 2016, 55, 14077-14080.

Publications