Catalytic Asymmetric Hydroamination of Unactivated Internal Olefins to Aliphatic Amines
“Catalytic Asymmetric Hydroamination of Unactivated Internal Olefins to Aliphatic Amines”, Science, 2015, 349(6243), 62 - 66.
Catalytic assembly of enantiopure aliphatic amines from abundant and readily available precursors has long been recognized as a paramount challenge in synthetic chemistry. Here, we describe a mild and general copper-catalyzed hydroamination that effectively converts unactivated internal olefins—an important yet unexploited class of abundant feedstock chemicals—into highly enantioenriched α-branched amines (≥96% enantiomeric excess) featuring two minimally differentiated aliphatic substituents. This method provides a powerful means to access a broad range of advanced, highly functionalized enantioenriched amines of interest in pharmaceutical research and other areas.