Flow Chemistry

Publications utilizing flow chemistry.

Rapid and Efficient Copper-Catalyzed Finkelstein Reaction of (Hetero)Aromatics under Continuous-Flow Conditions

M. Chen, Ichikawa, S. , and Buchwald, S. L. “Rapid and Efficient Copper-Catalyzed Finkelstein Reaction of (Hetero)Aromatics under Continuous-Flow Conditions”, Angew. Chem. Int. Ed., 2014, 54, 263-266.

Enantioselective β-arylation of ketones enabled by lithiation/borylation/1,4-addition sequence under flow conditions

W. Shu and Buchwald, S. L. “Enantioselective β-arylation of ketones enabled by lithiation/borylation/1,4-addition sequence under flow conditions”, Angew. Chem. Int. Ed., 2012, 51, 5355-5358.

Continuous-Flow Preparation and Use of β-Chloro Enals Using the Vilsmeier Reagent

L. Pellegatti and Buchwald, S. L. “Continuous-Flow Preparation and Use of β-Chloro Enals Using the Vilsmeier Reagent”, Org. Process Res. Dev., 2012, 16, 1442-1448.

Continuous-flow synthesis of biaryls enabled by multistep solid-handling in a lithiation/borylation/Suzuki-Miyaura cross-coupling sequence

W. Shu, Pellegatti, L. , Oberli, M. A. , and Buchwald, S. L. “Continuous-flow synthesis of biaryls enabled by multistep solid-handling in a lithiation/borylation/Suzuki-Miyaura cross-coupling sequence”, Angew. Chem. Int. Ed., 2011, 50(45), 10665-10669.

Use of precatalysts greatly facilitate palladium-catalyzed alkynylations in batch and continuous-flow conditions

W. Shu and Buchwald, S. L. “Use of precatalysts greatly facilitate palladium-catalyzed alkynylations in batch and continuous-flow conditions”, Chem. Sci., 2011, 2, 2321-2325.

Palladium-catalyzed amination reactions in flow: overcoming the challenges of clogging via acoustic irradiation

T. Noël, Naber, J. R. , Hartman, R. L. , McMullen, J. P. , Jensen, K. F. , and Buchwald, S. L. “Palladium-catalyzed amination reactions in flow: overcoming the challenges of clogging via acoustic irradiation”, Chem. Sci., 2011, 2, 287-290.

Accelerating Palladium-Catalyzed C-F Bond Formation: Use of a Microflow Packed-Bed Reactor

T. Noël, Maimone, T. J. , and Buchwald, S. L. “Accelerating Palladium-Catalyzed C-F Bond Formation: Use of a Microflow Packed-Bed Reactor”, Angew. Chem. Int. Ed., 2011, 50(38), 8900-8903.

Packed-bed reactors for continuous-flow C-N cross-coupling

J. R. Naber and Buchwald, S. L. “Packed-bed reactors for continuous-flow C-N cross-coupling”, Angew. Chem. Int. Ed., 2010, 49(49), 9469-9474.

Overcoming the Challenges of Solid Bridging and Constriction during Pd-Catalyzed C-N Bond Formation in Microreactors

R. L. Hartman, Naber, J. R. , Zaborenko, N. , Buchwald, S. L. , and Jensen, K. F. “Overcoming the Challenges of Solid Bridging and Constriction during Pd-Catalyzed C-N Bond Formation in Microreactors”, Org. Process Res. Dev., 2010, 14(39), 1347-1357.

Rapid and Efficient Trifluoromethylation of Aromatic and Heteroaromatic Compounds Using Potassium Trifluoroacetate Enabled by a Flow System

M. Chen and Buchwald, S. L. “Rapid and Efficient Trifluoromethylation of Aromatic and Heteroaromatic Compounds Using Potassium Trifluoroacetate Enabled by a Flow System”, Angew. Chem. Int. Ed., 2013, 52(44), 11628 - 11631.

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