Flow Chemistry

Publications utilizing flow chemistry.

Engineering Bioactive Dimeric Transcription Factor Analogs via Palladium Rebound Reagents

M. Jbara, Pomplun, S. , Schissel, C. K. , Hawken, S. Wilson, Boija, A. , Klein, I. , Rodriguez, J. , Buchwald, S. L. , and Pentelute, B. L. “Engineering Bioactive Dimeric Transcription Factor Analogs via Palladium Rebound Reagents”, J. Am. Chem. Soc., 2021, 143, 11788-11798.

Microfluidic electrochemistry for single-electron transfer redox-neutral reactions

Y. Mo, Lu, Z. , Rughoobur, G. , Patil, P. , Gershenfeld, N. , Akinwande, A. I. , Buchwald, S. L. , and Jensen, K. F. “Microfluidic electrochemistry for single-electron transfer redox-neutral reactions”, Science, 2020, 368(6497), 1352-1357.

Visible Light-Mediated (Hetero)aryl Amination Using Ni(II) Salts and Photoredox Catalysis in Flow: A Synthesis of Tetracaine

B. Y. Park, Pirnot, M. T. , and Buchwald, S. L. “Visible Light-Mediated (Hetero)aryl Amination Using Ni(II) Salts and Photoredox Catalysis in Flow: A Synthesis of Tetracaine”, J. Org. Chem., 2020, 85(5), 3234-3244.

Use of a Droplet Platform To Optimize Pd-Catalyzed C–N Coupling Reactions Promoted by Organic Bases

L. M. Baumgartner, Dennis, J. M. , White, N. A. , Buchwald, S. L. , and Jensen, K. F. “Use of a Droplet Platform To Optimize Pd-Catalyzed C–N Coupling Reactions Promoted by Organic Bases”, Org. Process Res. Dev., 2019, 23(8), 1594-1601.

Catalytic Arylhydroxylation of Dehydroalanine in Continuous Flow for Simple Access to Unnatural Amino Acids

K. M. R. Khan, Zhao, Y. , Scully, T. , and Buchwald, S. L. “Catalytic Arylhydroxylation of Dehydroalanine in Continuous Flow for Simple Access to Unnatural Amino Acids”, Chem. Eur. J., 2018, 24, 15215-15218.

Palladium-Catalyzed Negishi Coupling of α-CF3 Oxiranyl Zincate: Access to Chiral CF3-substituted Benzylic Tertiary Alcohols

H. Zhang and Buchwald, S. L. “Palladium-Catalyzed Negishi Coupling of α-CF3 Oxiranyl Zincate: Access to Chiral CF3-substituted Benzylic Tertiary Alcohols”, J. Am. Chem. Soc, 2017, 139, 11590-11594.

Suzuki-Miyaura cross-coupling optimization enabled by automated feedback

B. J. Reizman, Wang, Y. - M. , Buchwald, S. L. , and Jensen, K. F. “Suzuki-Miyaura cross-coupling optimization enabled by automated feedback”, Reaction Chemistry & Engineering, 2016, 1, 658-666 .

Rapid Synthesis of Aryl Fluorides in Continuous Flow through the Balz–Schiemann Reaction

N. H. Park, Senter, T. J. , and Buchwald, S. L. “Rapid Synthesis of Aryl Fluorides in Continuous Flow through the Balz–Schiemann Reaction”, Angew. Chem. Int. Ed. , 2016, 55(39), 11907-11911.

Continuous-Flow Synthesis of Biaryls by Negishi Cross-Coupling of Fluoro- and Trifluoromethyl-Substituted (Hetero)arenes

S. Roesner and Buchwald, S. L. “Continuous-Flow Synthesis of Biaryls by Negishi Cross-Coupling of Fluoro- and Trifluoromethyl-Substituted (Hetero)arenes”, Angew. Chem. Int. Ed., 2016, 55, 10463-10467.

Use of a “Catalytic” Cosolvent, N,N-Dimethyl Octanamide, Allows the Flow Synthesis of Imatinib with no Solvent Switch

J. C. Yang, Niu, D. , Karsten, B. P. , Lima, F. , and Buchwald, S. L. “Use of a “Catalytic” Cosolvent, N,N-Dimethyl Octanamide, Allows the Flow Synthesis of Imatinib with no Solvent Switch”, Angew. Chem. Int. Ed., 2016, 55, 2531-2535.

Pages