Copper

Copper-catalyzed reactions.

Catalytic Asymmetric Synthesis of α-Arylpyrrolidines and Benzo-fused Nitrogen Heterocycles

X. - J. Dai, Engl, O. D. , León, T. , and Buchwald, S. L. “Catalytic Asymmetric Synthesis of α-Arylpyrrolidines and Benzo-fused Nitrogen Heterocycles”, Angew. Chem. Int. Ed., 2019, 58(11), 3407-3411.

A Practical Electrophilic Nitrogen Source for the Synthesis of Chiral Primary Amines by Copper-Catalyzed Hydroamination

S. Guo, Yang, J. C. , and Buchwald, S. L. “A Practical Electrophilic Nitrogen Source for the Synthesis of Chiral Primary Amines by Copper-Catalyzed Hydroamination”, J. Am. Chem. Soc., 2018, 140, 15976-15984.

Mechanistically Guided Design of Ligands that Significantly Improve the Efficiency of CuH-Catalyzed Hydroamination Reactions

A. A. Thomas, Speck, K. , Kevlishvili, I. , Lu, Z. , Liu, P. , and Buchwald, S. L. “Mechanistically Guided Design of Ligands that Significantly Improve the Efficiency of CuH-Catalyzed Hydroamination Reactions”, J. Am. Chem. Soc., 2018, 140 (42), 13976-13984.

A Modified System for the Synthesis of Enantioenriched N‐Arylamines through Copper‐Catalyzed Hydroamination

S. Ichikawa, Zhu, S. , and Buchwald, S. L. “A Modified System for the Synthesis of Enantioenriched N‐Arylamines through Copper‐Catalyzed Hydroamination”, Angew. Chem. Int. Ed., 2018, 57, 8714-8718.

CuH‐Catalyzed Asymmetric Hydroamidation of Vinylarenes

Y. Zhou, Engl, O. D. , Bandar, J. S. , Chant, E. D. , and Buchwald, S. L. “CuH‐Catalyzed Asymmetric Hydroamidation of Vinylarenes”, Angew. Chem. Int. Ed., 2018, 57, 6672-6675.

Copper-Catalyzed Enantioselective Hydroamination of Alkenes

R. Y. Liu and Buchwald, S. L. “Copper-Catalyzed Enantioselective Hydroamination of Alkenes”, Org. Syn., 2018, 95, 80-96.

Asymmetric Cu-Catalyzed 1,4-Dearomatization of Pyridines and Pyridazines without Preactivation of the Heterocycle or Nucleophile

M. W. Gribble, Guo, S. , and Buchwald, S. L. “Asymmetric Cu-Catalyzed 1,4-Dearomatization of Pyridines and Pyridazines without Preactivation of the Heterocycle or Nucleophile”, J. Am. Chem. Soc., 2018, 140(15), 5057-5060.

A Regio- and Enantioselective CuH-Catalyzed Ketone Allylation with Terminal Allenes

E. Tsai, Liu, R. Y. , Yang, Y. , and Buchwald, S. L. “A Regio- and Enantioselective CuH-Catalyzed Ketone Allylation with Terminal Allenes”, J. Am. Chem. Soc, 2018, 140, 2007-2011.

Mechanistic Insight Facilitates Discovery of a Mild and Efficient Copper-Catalyzed Dehydration of Primary Amides to Nitriles Using Hydrosilanes

R. Y. Liu, Bae, M. , and Buchwald, S. L. “Mechanistic Insight Facilitates Discovery of a Mild and Efficient Copper-Catalyzed Dehydration of Primary Amides to Nitriles Using Hydrosilanes”, J. Am. Chem. Soc., 2018, 140, 1627-1631.

CuH-Catalyzed Asymmetric Reduction of α,β-Unsaturated Carboxylic Acids to β-Chiral Aldehydes

Y. Zhou, Bandar, J. S. , Liu, R. Y. , and Buchwald, S. L. “CuH-Catalyzed Asymmetric Reduction of α,β-Unsaturated Carboxylic Acids to β-Chiral Aldehydes”, J. Am. Chem. Soc, 2018, 140, 606-609.

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