Copper

Copper-catalyzed reactions.

Confronting the Challenging Asymmetric Carbonyl 1,2-Addition Using Vinyl Heteroarene Pronucleophiles: Ligand-Controlled Regiodivergent Processes through a Dearomatized Allyl–Cu Species

Y. Dong, Schuppe, A. W. , Mai, B. Khah, Liu, P. , and Buchwald, S. L. “Confronting the Challenging Asymmetric Carbonyl 1,2-Addition Using Vinyl Heteroarene Pronucleophiles: Ligand-Controlled Regiodivergent Processes through a Dearomatized Allyl–Cu Species”, J. Am. Chem. Soc., 2022, 144(13), 5985-5995.

A Dual CuH- and Pd-Catalyzed Stereoselective Synthesis of Highly Substituted 1,3-Dienes

C. - J. Hou, Schuppe, A. W. , Knippel, J. Levi, Ni, A. Z. , and Buchwald, S. L. “A Dual CuH- and Pd-Catalyzed Stereoselective Synthesis of Highly Substituted 1,3-Dienes”, Org. Lett., 2021, 23(22), 8816-8821.

Enantioselective Hydroalkenylation of Olefins with Enol Sulfonates Enabled by Dual Copper Hydride and Palladium Catalysis

A. W. Schuppe, Knippel, J. Levi, Borrajo-Calleja, G. M. , and Buchwald, S. L. “Enantioselective Hydroalkenylation of Olefins with Enol Sulfonates Enabled by Dual Copper Hydride and Palladium Catalysis”, J. Am. Chem. Soc. , 2021, 143, 5330-5335.

CuH-Catalyzed Regio- and Enantioselective Hydrocarboxylation of Allenes; Toward Carboxylic Acids with Acyclic Quarternary Centers

S. Feng and Buchwald, S. L. “CuH-Catalyzed Regio- and Enantioselective Hydrocarboxylation of Allenes; Toward Carboxylic Acids with Acyclic Quarternary Centers”, J. Am. Chem. Soc., 2021, 143(13), 4935-4941.

Enantioselective C2-Allylation of Benzimidazoles Using 1,3-Diene Pronucleophiles

J. Levi Knippel, Ye, Y. , and Buchwald, S. L. “Enantioselective C2-Allylation of Benzimidazoles Using 1,3-Diene Pronucleophiles”, Org. Lett., 2021, 23, 2153-2157.

Enantioselective Synthesis of β-Amino Acid Derivatives Enabled by Ligand-Controlled Reversal of Hydrocupration Regiochemistry

S. Guo, Zhu, J. , and Buchwald, S. L. “Enantioselective Synthesis of β-Amino Acid Derivatives Enabled by Ligand-Controlled Reversal of Hydrocupration Regiochemistry”, Angew. Chem. Int. Ed., 2020, 59, 20841-20845.

CuH-Catalyzed Asymmetric Reductive Amidation of α,β-Unsaturated Carboxylic Acids

A. Link, Zhou, Y. , and Buchwald, S. L. “CuH-Catalyzed Asymmetric Reductive Amidation of α,β-Unsaturated Carboxylic Acids”, Org. Lett., 2020, 22(14), 5666-5670.

Evidence for Simultaneous Dearomatization of Two Aromatic Rings Under Mild Conditions in Cu(I)-Catalyzed Direct Asymmetric Dearomatization of Pyridine

M. W. Gribble, Liu, R. Y. , and Buchwald, S. L. “Evidence for Simultaneous Dearomatization of Two Aromatic Rings Under Mild Conditions in Cu(I)-Catalyzed Direct Asymmetric Dearomatization of Pyridine”, J. Am. Chem. Soc., 2020, 142(25), 11252-11269.

The Enantioselective Preparation of Arenes with β-Stereogenic Centers: Confronting the 1,1-Disubstituted Olefin Problem Using CuH/Pd Cooperative Catalysis

Z. Lu and Buchwald, S. L. “The Enantioselective Preparation of Arenes with β-Stereogenic Centers: Confronting the 1,1-Disubstituted Olefin Problem Using CuH/Pd Cooperative Catalysis”, Angew. Chem. Int. Ed., 2020, https://doi.org/10.1002/anie.202004414.

Highly Enantioselective Synthesis of Indazoles with a C3-Quaternary Chiral Center Using CuH Catalysis

Y. Ye, Kevlishvili, I. , Feng, S. , Liu, P. , and Buchwald, S. L. “Highly Enantioselective Synthesis of Indazoles with a C3-Quaternary Chiral Center Using CuH Catalysis”, J. Am. Chem. Soc., 2020, 142(23), 10550-10556.

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